Across TCGA patient cohorts, LRRK2 RNA expression is significantly associated with the protein abundance of many other proteins, with 20,771 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible LRRK2-associated proteins across cancer lineages are EVL, ALDH18A1, and HSPD1. Each is linked with LRRK2 in more than 7 cancer types. Because this analysis shows association rather than direction, both LRRK2-to-partner and partner-to-LRRK2 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRK2→partner) and Y-score (partner→LRRK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	EVL →	+0.758	+1.061	<.001	<.001	3	8
UCEC	ALDH18A1 →	-0.472	-0.806	<.001	<.001	3	8
LUAD	HSPD1 →	-0.412	-1.059	<.001	<.001	3	8
LSCC	LRPPRC →	-0.489	-1.445	<.001	<.001	3	8
OV	MYO1G →	+0.514	+0.997	<.001	<.001	3	7
OV	NCOA7_S89 →	+0.808	+0.826	.001	.002	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 20,771 associations by consensus.

Exploration

LRRK2 survival (RNA) · tumor vs normal (RNA) · all LRRK2 data types