Across TCGA patient cohorts, LRRK2 mutation is significantly associated with the RNA expression of many other genes, with 7,089 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRK2-associated genes across cancer lineages are FEN1, SAAL1, and CHAF1A. Each is linked with LRRK2 in more than 6 cancer types. Because this analysis shows association rather than direction, both LRRK2-to-partner and partner-to-LRRK2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRK2→partner) and Y-score (partner→LRRK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FEN1 →	+0.476	+1.280	<.001	<.001	3	7
SKCM	SAAL1 →	+0.387	+2.179	<.001	<.001	3	6
UCEC	CHAF1A →	+0.595	+1.828	<.001	<.001	3	6
UCEC	H2AZ1 →	+0.453	+1.546	<.001	<.001	3	6
UCEC	CDC45 →	+0.511	+1.568	<.001	<.001	3	6
HNSC	CACYBP →	+0.531	+2.607	<.001	.005	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,089 associations by consensus.

Exploration

LRRK2 survival (RNA) · tumor vs normal (RNA) · all LRRK2 data types