Across TCGA cell cohorts, LRRK2 mutation is significantly associated with the RNA expression of many other genes, with 1,095 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LRRK2-associated genes across cancer lineages are BBS7, TNK1, and KLHL11. Each is linked with LRRK2 in more than 2 cancer types. Because this analysis shows association rather than direction, both LRRK2-to-partner and partner-to-LRRK2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRK2→partner) and Y-score (partner→LRRK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	BBS7 →	+0.483	+2.000	.002	.004	3	3
LARGE_INTESTINE	TNK1 →	+0.786	+2.971	<.001	<.001	3	3
LARGE_INTESTINE	KLHL11 →	+0.650	+2.000	<.001	.004	3	3
LARGE_INTESTINE	ADH5 →	+0.534	+2.082	.001	.002	3	3
SOFT_TISSUE	EPB42 →	+0.006	+5.977	<.001	.001	3	2
LARGE_INTESTINE	RPS6KA5 →	+0.628	+2.000	.004	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,095 associations by consensus.

Exploration

LRRK2 survival (RNA) · tumor vs normal (RNA) · all LRRK2 data types