LRRK1

Across TCGA pan-cancer cohorts, LRRK1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated LRRK1 data layer compared with 26 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher LRRK1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated LRRK1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and HNSC show a favorable association.

PDAC, LUAD, and GBM are the cancer types where LRRK1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Quartile	All	0.372	0.917	.001	37	view →
LUAD	DFS	Median	All	0.947	0.854	<.001	18	view →
GBM	DFS	Tertile	All	0.292	0.626	.023	10	view →
HNSC	OS	Tertile	All	0.804	0.436	.020	6	view →
UCEC	DFS	Median	All	0.808	1.000	.018	2	view →
LSCC	DFS	Median	II,III,IV	0.709	0.848	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

LRRK1–PDAC (DFS)

Open the PDAC breakdown →