LRRK1

Across TCGA patient cohorts, LRRK1 RNA expression is significantly associated with the protein abundance of many other proteins, with 12,923 significant associations in total. GBM shows the largest number of these associations.

The most reproducible LRRK1-associated proteins across cancer lineages are CSK, ELMO1, and IRF5. Each is linked with LRRK1 in more than 5 cancer types. Because this analysis shows association rather than direction, both LRRK1-to-partner and partner-to-LRRK1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LRRK1 versus CSK in GBM, with a Pearson correlation of 0.59.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRK1→partner) and Y-score (partner→LRRK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CSK →	+0.370	+0.833	<.001	<.001	3	6
GBM	ELMO1 →	+0.548	+0.723	<.001	<.001	3	6
GBM	IRF5 →	+0.286	+0.584	<.001	<.001	3	6
BRCA	ITGAL →	+0.673	+0.651	<.001	<.001	3	6
GBM	ITGAX →	+0.566	+0.543	<.001	<.001	3	6
GBM	TBC1D2B →	+0.348	+0.656	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,923 associations by consensus.

LRRK1 vs CSK — GBM

Explore this scatter interactively →