LRRK1

Across TCGA patient cohorts, LRRK1 protein abundance is significantly associated with the RNA expression of many other genes, with 10,536 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible LRRK1-associated genes across cancer lineages are WAS, LCP2, and CYTIP. Each is linked with LRRK1 in more than 5 cancer types. Because this analysis shows association rather than direction, both LRRK1-to-partner and partner-to-LRRK1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LRRK1 versus WAS in GBM, with a Pearson correlation of 0.53.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRK1→partner) and Y-score (partner→LRRK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	WAS →	+0.832	+0.407	<.001	<.001	3	6
UCEC	LCP2 →	+1.129	+0.555	<.001	.002	3	6
BRCA	CYTIP →	+1.213	+0.575	<.001	<.001	3	5
GBM	IL18RAP →	+1.014	+0.418	<.001	.002	3	5
UCEC	LILRB2 →	+1.038	+0.543	<.001	.001	3	5
GBM	IL2RA →	+1.499	+0.450	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,536 associations by consensus.

LRRK1 vs WAS — GBM

Explore this scatter interactively →