LRRK1

Across TCGA patient cohorts, LRRK1 mutation is significantly associated with the total protein of many other genes, with 94 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRK1-associated genes across cancer lineages are Cyclin-B1, TFRC, and Caspase-7-cleavedD198. Each is linked with LRRK1 in more than 4 cancer types. Because this analysis shows association rather than direction, both LRRK1-to-partner and partner-to-LRRK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by LRRK1-low versus LRRK1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRK1→partner) and Y-score (partner→LRRK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.622	+4.584	<.001	<.001	3	5
LUAD	TFRC →	+0.628	+1.874	.002	.049	3	4
COAD	Caspase-7-cleavedD198 →	+1.097	+3.186	<.001	.009	3	4
COAD	PCNA →	+0.248	+2.008	.013	.018	3	4
STAD	ASNS →	+0.491	+2.321	.013	.034	3	3
LUSC	eIF4E →	+0.166	+2.331	.016	.019	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 94 associations by consensus.

Cyclin-B1 by LRRK1 expression — UCEC

Explore this box plot interactively →