LRRK1

Across TCGA cell cohorts, LRRK1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,175 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible LRRK1-associated GO terms across cancer lineages are Regulation of fibroblast proliferation, Fibroblast migration, and Interferon-mediated signaling pathway. Each is linked with LRRK1 in more than 10 cancer types. Because this analysis shows association rather than direction, both LRRK1-to-partner and partner-to-LRRK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of fibroblast proliferation grouped by LRRK1-low versus LRRK1-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRK1→partner) and Y-score (partner→LRRK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Regulation of fibroblast proliferation →	+0.113	+1.490	<.001	<.001	3	11
STOMACH	Fibroblast migration →	+0.237	+1.573	.001	.009	3	10
BLOOD_Myeloma	Interferon-mediated signaling pathway →	+0.114	+2.401	.007	.007	3	10
OESOPHAGUS	Viral genome replication →	+0.146	+1.273	.003	.002	3	9
BONE	Actin filament organization →	+0.119	+1.527	<.001	<.001	3	9
BONE	Positive regulation of protein localization to plasma membrane →	+0.118	+1.844	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,175 associations by consensus.

Regulation of fibroblast proliferation by LRRK1 expression — BREAST

Explore this box plot interactively →