LRRK1

Across TCGA cell cohorts, LRRK1 mutation is significantly associated with the RNA expression of many other genes, with 1,030 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LRRK1-associated genes across cancer lineages are TLE2, OR9A2, and GAB4. Each is linked with LRRK1 in more than 2 cancer types. Because this analysis shows association rather than direction, both LRRK1-to-partner and partner-to-LRRK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TLE2 grouped by LRRK1-low versus LRRK1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRK1→partner) and Y-score (partner→LRRK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TLE2 →	+1.450	+2.489	<.001	.007	3	3
URINARY_TRACT	OR9A2 →	+0.019	+3.050	.003	.007	3	2
LUNG_SCLC	GAB4 →	+0.195	+2.807	<.001	.001	3	2
LUNG_SCLC	GOLGA6L22 →	+0.024	+2.611	.002	.006	2	3
LARGE_INTESTINE	GPR63 →	+0.820	+2.700	<.001	.001	3	2
LUNG_NSCLC_LUAD	OPN1MW2 →	+0.024	+2.788	.002	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,030 associations by consensus.

TLE2 by LRRK1 expression — BLOOD_Leukemia

Explore this box plot interactively →