Across TCGA patient cohorts, LRRIQ4 mutation is significantly associated with the RNA expression of many other genes, with 1,736 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible LRRIQ4-associated genes across cancer lineages are VPS26C, HSPA4L, and MAP3K9. Each is linked with LRRIQ4 in more than 2 cancer types. Because this analysis shows association rather than direction, both LRRIQ4-to-partner and partner-to-LRRIQ4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRIQ4→partner) and Y-score (partner→LRRIQ4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VPS26C →	+0.358	+2.716	.008	.003	3	3
UCEC	HSPA4L →	+0.570	+1.869	.007	.005	3	3
UCEC	MAP3K9 →	+0.446	+3.470	.002	.002	3	3
LGG	RN7SL332P →	+0.197	+6.363	<.001	.001	3	3
SKCM	TSPY26P →	-0.796	-1.838	<.001	<.001	3	3
SKCM	SEPTIN7P14 →	+0.407	+1.656	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,736 associations by consensus.

Exploration

LRRIQ4 survival (RNA) · tumor vs normal (RNA) · all LRRIQ4 data types