Across TCGA patient cohorts, LRRIQ4 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRIQ4-associated genes across cancer lineages are eEF2, 4E-BP1, and ERK2. Each is linked with LRRIQ4 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRIQ4-to-partner and partner-to-LRRIQ4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRIQ4→partner) and Y-score (partner→LRRIQ4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	eEF2 →	+0.523	+2.815	.001	.036	3	2
COAD	4E-BP1 →	+0.274	+2.815	.022	.036	3	2
UCEC	ERK2 →	+0.169	+1.700	.038	.044	3	2
UCEC	STAT3_pY705 →	-0.414	-1.690	<.001	.042	3	2
UCEC	AR →	-0.410	-3.169	.009	.018	3	2
UCEC	ATM →	-0.651	-2.906	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

Exploration

LRRIQ4 survival (RNA) · tumor vs normal (RNA) · all LRRIQ4 data types