Across TCGA cell cohorts, LRRIQ4 mutation is significantly associated with the RNA expression of many other genes, with 23 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible LRRIQ4-associated genes across cancer lineages are GAGE12E, SPATA31A1, and KRTAP16-1. Each is linked with LRRIQ4 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRIQ4-to-partner and partner-to-LRRIQ4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRIQ4→partner) and Y-score (partner→LRRIQ4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	GAGE12E →	+0.090	+4.930	<.001	.008	3	1
PANCREAS	SPATA31A1 →	+0.004	+4.029	<.001	.007	3	1
PANCREAS	KRTAP16-1 →	+0.013	+4.029	<.001	.007	3	1
LUNG_SCLC	GGTLC1 →	+0.016	+3.169	<.001	.005	3	1
LUNG_SCLC	KRT79 →	+0.462	+3.381	.007	.007	3	1
LUNG_SCLC	GPX6 →	+0.030	+3.169	.007	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

Exploration

LRRIQ4 survival (RNA) · tumor vs normal (RNA) · all LRRIQ4 data types