LRRIQ3

Across TCGA patient cohorts, LRRIQ3 mutation is significantly associated with the total protein of many other genes, with 65 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRIQ3-associated genes across cancer lineages are 4E-BP1, Cyclin-B1, and PCNA. Each is linked with LRRIQ3 in more than 3 cancer types. Because this analysis shows association rather than direction, both LRRIQ3-to-partner and partner-to-LRRIQ3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by LRRIQ3-low versus LRRIQ3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRIQ3→partner) and Y-score (partner→LRRIQ3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.366	+2.532	<.001	<.001	3	4
UCEC	Cyclin-B1 →	+0.543	+1.874	.004	.049	3	3
UCEC	PCNA →	+0.159	+3.169	.030	.018	3	3
UCEC	ATM →	-0.497	-1.514	.001	.015	3	3
LUSC	p70-S6K →	+0.332	+3.000	.002	.035	3	2
LUAD	PRDX1 →	+0.331	+3.016	.003	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 65 associations by consensus.

4E-BP1 by LRRIQ3 expression — UCEC

Explore this box plot interactively →