LRRIQ3

Across TCGA cell cohorts, LRRIQ3 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,466 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LRRIQ3-associated GO terms across cancer lineages are Protein localization to cilium, Protein localization to ciliary membrane, and Regulation of DNA damage checkpoint. Each is linked with LRRIQ3 in more than 10 cancer types. Because this analysis shows association rather than direction, both LRRIQ3-to-partner and partner-to-LRRIQ3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein localization to cilium grouped by LRRIQ3-low versus LRRIQ3-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRIQ3→partner) and Y-score (partner→LRRIQ3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Protein localization to cilium →	+0.052	+0.705	<.001	.002	2	11
BREAST	Protein localization to ciliary membrane →	+0.115	+0.718	.001	.002	3	8
UPPER_AERODIGESTIVE_TRACT	Regulation of DNA damage checkpoint →	+0.103	+0.712	<.001	<.001	3	8
OVARY	Methylation →	+0.039	+0.480	.007	.003	3	8
UPPER_AERODIGESTIVE_TRACT	Regulation of centriole replication →	+0.080	+0.703	.004	.003	3	8
LARGE_INTESTINE	Intraciliary anterograde transport →	+0.047	+0.277	.003	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,466 associations by consensus.

Protein localization to cilium by LRRIQ3 expression — LUNG_SCLC

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