LRRIQ3

Across TCGA cell cohorts, LRRIQ3 mutation is significantly associated with the RNA expression of many other genes, with 127 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LRRIQ3-associated genes across cancer lineages are BNIP5, APELA, and MROH9. Each is linked with LRRIQ3 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRIQ3-to-partner and partner-to-LRRIQ3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BNIP5 grouped by LRRIQ3-low versus LRRIQ3-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRIQ3→partner) and Y-score (partner→LRRIQ3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	BNIP5 →	+0.019	+3.523	.001	.008	3	2
SKIN	APELA →	+0.034	+3.292	.009	.007	3	2
BREAST	MROH9 →	+0.029	+4.672	<.001	.002	3	2
LARGE_INTESTINE	PYGO2 →	+0.486	+3.064	.004	.009	3	2
LUNG_SCLC	TMEM82 →	+0.089	+3.523	<.001	.008	3	1
LUNG_SCLC	PSG2 →	+0.137	+4.070	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 127 associations by consensus.

BNIP5 by LRRIQ3 expression — SKIN

Explore this box plot interactively →