LRRIQ1

Across TCGA pan-cancer cohorts, LRRIQ1 Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated LRRIQ1 data layer compared with 22 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher LRRIQ1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated LRRIQ1 expression acts as an unfavorable survival marker, although some lineages such as STAD and SKCM show a favorable association.

LUSC, COAD, and LIHC are the cancer types where LRRIQ1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Median	IV	0.057	0.786	.008	18	view →
COAD	OS	Median	III,IV	0.147	0.800	<.001	15	view →
LIHC	OS	Median	All	0.213	0.684	<.001	12	view →
MESO	DFS	Median	III,IV	0.078	0.376	.012	9	view →
STAD	DFS	Median	III,IV	1.000	0.334	.023	9	view →
SKCM	DFS	Median	II,III,IV	0.820	0.659	.018	9	view →
UCEC	DFS	Median	All	0.933	0.826	.022	8	view →
READ	DFS	Median	IV	0.082	0.619	.001	6	view →
HNSC	OS	Median	II,III,IV	0.222	0.710	.031	6	view →
LUAD	DFS	Median	IV	0.342	0.893	<.001	6	view →
SCLC	OS	Median	All	0.888	0.544	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

LRRIQ1–LUSC (OS)

Open the LUSC breakdown →