LRRFIP2

Across TCGA patient cohorts, LRRFIP2 mutation is significantly associated with the RNA expression of many other genes, with 2,123 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRFIP2-associated genes across cancer lineages are MYO15B, MYO19, and IGKV2OR2-10. Each is linked with LRRFIP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRFIP2-to-partner and partner-to-LRRFIP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYO15B grouped by LRRFIP2-low versus LRRFIP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRFIP2→partner) and Y-score (partner→LRRFIP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MYO15B →	-0.490	-1.783	.009	.004	3	2
UCEC	MYO19 →	+0.409	+1.754	<.001	.001	3	2
BLCA	IGKV2OR2-10 →	+0.152	+3.320	.002	.008	3	2
UCEC	ESS2 →	+0.282	+2.283	<.001	<.001	3	2
UCEC	POLDIP3 →	+0.411	+2.081	<.001	<.001	3	2
UCEC	LMF2 →	+0.381	+2.321	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,123 associations by consensus.

MYO15B by LRRFIP2 expression — UCEC

Explore this box plot interactively →