LRRFIP2

Across TCGA patient cohorts, LRRFIP2 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRFIP2-associated genes across cancer lineages are INPP4B, MEK1, and Akt_pS473. Each is linked with LRRFIP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRFIP2-to-partner and partner-to-LRRFIP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by LRRFIP2-low versus LRRFIP2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRFIP2→partner) and Y-score (partner→LRRFIP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	INPP4B →	-0.395	-2.991	.041	.036	3	2
UCEC	MEK1 →	+0.354	+1.874	.003	.002	3	2
UCEC	Akt_pS473 →	+0.569	+1.584	.017	.034	3	2
UCEC	Akt_pT308 →	+0.580	+1.584	.005	.009	3	2
UCEC	PCNA →	+0.163	+1.321	.024	.029	3	2
UCEC	PDCD4 →	-0.413	-1.321	.008	.029	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

INPP4B by LRRFIP2 expression — COAD

Explore this box plot interactively →