LRRFIP2

Across TCGA cell cohorts, LRRFIP2 mutation is significantly associated with the RNA expression of many other genes, with 30 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LRRFIP2-associated genes across cancer lineages are OR1P1, OR1G1, and CCL7. Each is linked with LRRFIP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRFIP2-to-partner and partner-to-LRRFIP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1P1 grouped by LRRFIP2-low versus LRRFIP2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRFIP2→partner) and Y-score (partner→LRRFIP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR1P1 →	+0.065	+4.887	<.001	.009	3	2
BLOOD_Leukemia	OR1G1 →	+0.072	+4.705	<.001	.003	3	2
BLOOD_Lymphoma	CCL7 →	+0.098	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	SMCP →	+0.040	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	KCNK18 →	+0.022	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	FABP12 →	+0.095	+5.643	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

OR1P1 by LRRFIP2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →