LRRFIP2

Across TCGA cell cohorts, LRRFIP2 mutation is significantly associated with the mutation status of many other genes, with 3,480 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LRRFIP2-associated genes across cancer lineages are ZNF197, GCN1, and KIF17. Each is linked with LRRFIP2 in more than 3 cancer types. Because this analysis shows association rather than direction, both LRRFIP2-to-partner and partner-to-LRRFIP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF197 grouped by LRRFIP2-low versus LRRFIP2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRFIP2→partner) and Y-score (partner→LRRFIP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ZNF197 →	+4.187	+5.000	.008	.008	1	4
SOFT_TISSUE	GCN1 →	+5.502	+5.502	.003	.003	1	4
UPPER_AERODIGESTIVE_TRACT	KIF17 →	+4.392	+4.954	.008	.008	1	4
UPPER_AERODIGESTIVE_TRACT	ITPKB →	+4.392	+4.954	.008	.008	1	4
UPPER_AERODIGESTIVE_TRACT	MGAT5 →	+4.392	+4.954	.008	.008	1	4
UPPER_AERODIGESTIVE_TRACT	CWF19L2 →	+5.392	+5.392	.004	.004	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,480 associations by consensus.

ZNF197 by LRRFIP2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →