LRRFIP1P1

Across TCGA patient cohorts, LRRFIP1P1 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRFIP1P1-associated genes across cancer lineages are Tuberin_pT1462, EGFR_pY1068, and A-Raf_pS299. Each is linked with LRRFIP1P1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRFIP1P1-to-partner and partner-to-LRRFIP1P1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Tuberin_pT1462 grouped by LRRFIP1P1-low versus LRRFIP1P1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRFIP1P1→partner) and Y-score (partner→LRRFIP1P1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Tuberin_pT1462 →	+0.299	+1.817	<.001	.015	3	2
UCEC	EGFR_pY1068 →	-0.278	-2.502	.004	.002	3	1
UCEC	A-Raf_pS299 →	-0.143	-2.321	.002	.033	3	1
UCEC	FoxM1 →	+0.216	+2.000	.034	.010	3	1
UCEC	FOXO3a_pS318_S321 →	-0.107	-1.700	.029	.040	3	1
UCEC	GATA6 →	-0.149	-1.700	.016	.042	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

Tuberin_pT1462 by LRRFIP1P1 expression — UCEC

Explore this box plot interactively →