LRRCC1

Across TCGA patient cohorts, LRRCC1 mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRCC1-associated genes across cancer lineages are ASNS, eIF4E, and JNK_pT183_Y185. Each is linked with LRRCC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both LRRCC1-to-partner and partner-to-LRRCC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by LRRCC1-low versus LRRCC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRCC1→partner) and Y-score (partner→LRRCC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.299	+1.415	.008	.043	3	3
UCEC	eIF4E →	+0.136	+1.887	.040	.029	3	2
UCEC	JNK_pT183_Y185 →	-0.176	-2.321	<.001	<.001	3	2
UCEC	JNK2 →	+0.254	+2.115	<.001	<.001	3	2
UCEC	MEK1 →	+0.341	+2.392	.003	<.001	3	2
UCEC	Notch1 →	+0.167	+1.857	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

ASNS by LRRCC1 expression — UCEC

Explore this box plot interactively →