LRRCC1

Across TCGA cell cohorts, LRRCC1 mutation is significantly associated with the RNA expression of many other genes, with 150 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LRRCC1-associated genes across cancer lineages are OR2T12, IFNG, and RFPL3. Each is linked with LRRCC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRCC1-to-partner and partner-to-LRRCC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2T12 grouped by LRRCC1-low versus LRRCC1-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRCC1→partner) and Y-score (partner→LRRCC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	OR2T12 →	+0.052	+3.906	.002	.009	3	1
BLOOD_Leukemia	IFNG →	+0.152	+3.567	<.001	.003	3	1
BLOOD_Leukemia	RFPL3 →	+0.042	+4.661	<.001	<.001	3	1
BLOOD_Leukemia	SPATA19 →	+0.015	+4.569	<.001	.003	3	1
BLOOD_Leukemia	WFDC12 →	+0.160	+3.289	<.001	.009	3	1
BLOOD_Leukemia	WFDC11 →	+0.037	+4.539	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 150 associations by consensus.

OR2T12 by LRRCC1 expression — BLOOD_Myeloma

Explore this box plot interactively →