LRRC9

Across TCGA cell cohorts, LRRC9 mutation is significantly associated with the RNA expression of many other genes, with 195 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LRRC9-associated genes across cancer lineages are GPR119, NCR1, and OR13C2. Each is linked with LRRC9 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC9-to-partner and partner-to-LRRC9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPR119 grouped by LRRC9-low versus LRRC9-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC9→partner) and Y-score (partner→LRRC9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	GPR119 →	+0.040	+4.906	<.001	.006	3	1
OESOPHAGUS	NCR1 →	+0.276	+4.906	<.001	.006	3	1
OESOPHAGUS	OR13C2 →	+0.033	+4.906	<.001	.006	3	1
LUNG_SCLC	RXFP2 →	+0.263	+4.044	<.001	.009	3	1
LUNG_SCLC	LYZL2 →	+0.020	+4.643	<.001	.004	3	1
LUNG_SCLC	OR10G3 →	+0.047	+4.643	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 195 associations by consensus.

GPR119 by LRRC9 expression — OESOPHAGUS

Explore this box plot interactively →