LRRC8D

Across TCGA pan-cancer cohorts, LRRC8D Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated LRRC8D data layer compared with 27 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher LRRC8D Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated LRRC8D expression acts as an unfavorable survival marker, although some lineages such as UCEC and BLCA show a favorable association.

UCEC, BLCA, and COAD are the cancer types where LRRC8D Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.975	0.613	.002	22	view →
BLCA	DFS	Median	All	1.000	0.323	.024	12	view →
COAD	OS	Median	III,IV	0.168	0.691	.041	6	view →
SKCM	DFS	Median	III,IV	0.087	0.647	.013	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

LRRC8D–UCEC (DFS)

Open the UCEC breakdown →