LRRC8D

Across TCGA pan-cancer cohorts, LRRC8D mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated LRRC8D data layer compared with 27 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher LRRC8D mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated LRRC8D expression acts as an unfavorable survival marker.

HNSC and CCRCC are the cancer types where LRRC8D mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	All	0.168	0.947	.017	12	view →
CCRCC	DFS	Tertile	IV	0.213	0.887	.024	6	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

LRRC8D–HNSC (OS)

Open the HNSC breakdown →