LRRC8D

Across TCGA patient cohorts, LRRC8D RNA expression is significantly associated with the protein abundance of many other proteins, with 17,536 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible LRRC8D-associated proteins across cancer lineages are ZNF326, FER, and MCM2. Each is linked with LRRC8D in more than 4 cancer types. Because this analysis shows association rather than direction, both LRRC8D-to-partner and partner-to-LRRC8D results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LRRC8D versus ZNF326 in HNSC, with a Pearson correlation of 0.41.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC8D→partner) and Y-score (partner→LRRC8D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ZNF326 →	+0.512	+0.902	<.001	.002	3	5
HNSC	FER →	-0.287	-0.915	<.001	<.001	3	5
UCEC	MCM2 →	+0.520	+0.579	<.001	<.001	3	5
BRCA	MTA2 →	+0.316	+0.575	<.001	<.001	3	5
LSCC	GCLM →	+1.009	+0.612	<.001	<.001	3	4
LSCC	PURA →	-0.301	-0.723	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,536 associations by consensus.

LRRC8D vs ZNF326 — HNSC

Explore this scatter interactively →