LRRC8D

Across TCGA patient cohorts, LRRC8D mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRC8D-associated genes across cancer lineages are FASN, p62 Lck ligand, and PCNA. Each is linked with LRRC8D in more than 2 cancer types. Because this analysis shows association rather than direction, both LRRC8D-to-partner and partner-to-LRRC8D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by LRRC8D-low versus LRRC8D-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC8D→partner) and Y-score (partner→LRRC8D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.255	+1.115	.026	.026	3	2
UCEC	p62 Lck ligand →	+0.317	+2.746	<.001	<.001	3	2
UCEC	PCNA →	+0.181	+1.485	.003	.003	3	2
UCEC	Annexin-1 →	+0.470	+2.906	.002	.001	3	2
UCEC	ATM →	-0.601	-1.906	<.001	<.001	3	2
UCEC	Chk2_pT68 →	-0.140	-1.295	.009	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

FASN by LRRC8D expression — UCEC

Explore this box plot interactively →