LRRC8D

Across TCGA cell cohorts, LRRC8D RNA expression is significantly associated with the go_rna of many other GO terms, with 3,543 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LRRC8D-associated GO terms across cancer lineages are C4-dicarboxylate transport, Protein hexamerization, and Regulation of nucleobase-containing compound transport. Each is linked with LRRC8D in more than 8 cancer types. Because this analysis shows association rather than direction, both LRRC8D-to-partner and partner-to-LRRC8D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C4-dicarboxylate transport grouped by LRRC8D-low versus LRRC8D-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC8D→partner) and Y-score (partner→LRRC8D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	C4-dicarboxylate transport →	+0.119	+1.107	<.001	.001	3	9
LIVER	Protein hexamerization →	+0.164	+1.132	<.001	<.001	3	9
OVARY	Regulation of nucleobase-containing compound transport →	+0.096	+0.807	.001	<.001	3	9
PANCREAS	Vascular endothelial cell response to fluid shear stress →	+0.112	+0.911	.001	<.001	3	8
LARGE_INTESTINE	Regulation of RNA export from nucleus →	+0.099	+0.650	<.001	.001	3	8
BREAST	Response to thyroxine →	+0.150	+0.828	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,543 associations by consensus.

C4-dicarboxylate transport by LRRC8D expression — SOFT_TISSUE

Explore this box plot interactively →