LRRC8D

Across TCGA cell cohorts, LRRC8D mutation is significantly associated with the RNA expression of many other genes, with 30 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LRRC8D-associated genes across cancer lineages are HRG, DSG1, and KAAG1. Each is linked with LRRC8D in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC8D-to-partner and partner-to-LRRC8D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HRG grouped by LRRC8D-low versus LRRC8D-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC8D→partner) and Y-score (partner→LRRC8D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	HRG →	+0.352	+4.177	<.001	.001	3	1
BLOOD_Leukemia	DSG1 →	+0.145	+3.594	<.001	.007	3	1
BLOOD_Leukemia	KAAG1 →	+0.081	+4.177	<.001	.001	3	1
BLOOD_Leukemia	ASZ1 →	+0.100	+4.889	.001	<.001	3	1
BLOOD_Leukemia	SPATA19 →	+0.015	+4.569	<.001	.003	3	1
BLOOD_Leukemia	WFDC12 →	+0.171	+4.289	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

HRG by LRRC8D expression — BLOOD_Leukemia

Explore this box plot interactively →