LRRC8A

Across TCGA pan-cancer cohorts, LRRC8A Mutation is linked to patient survival in 1 of 34 cancer types, making it a survival-associated LRRC8A data layer compared with 27 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in thyroid carcinoma (THCA), where higher LRRC8A Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated LRRC8A expression acts as an unfavorable survival marker.

THCA are the cancer types where LRRC8A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THCA	DFS	Median	All	0.136	0.842	.002	12	view →

Pink = unfavorable, green = favorable. Showing the 1 strongest of 1 lineages.

LRRC8A–THCA (DFS)

Open the THCA breakdown →