LRRC8A

Across TCGA pan-cancer cohorts, LRRC8A mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated LRRC8A data layer compared with 27 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher LRRC8A mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated LRRC8A expression acts as an unfavorable survival marker, although some lineages such as CCRCC and UCEC show a favorable association.

CCRCC, UCEC, and HNSC are the cancer types where LRRC8A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	All	1.000	0.886	.004	75	view →
UCEC	OS	Median	II,III,IV	1.000	0.609	.008	14	view →
HNSC	DFS	Median	All	0.994	0.909	.005	12	view →
LUAD	OS	Quartile	III,IV	0.797	0.292	.026	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

LRRC8A–CCRCC (OS)

Open the CCRCC breakdown →