LRRC7

Across TCGA pan-cancer cohorts, LRRC7 Mutation is linked to patient survival in 12 of 34 cancer types, making it a survival-associated LRRC7 data layer compared with 22 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher LRRC7 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated LRRC7 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, DLBC, and ESCA are the cancer types where LRRC7 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.783	0.621	<.001	32	view →
DLBC	DFS	Median	II,III,IV	0.065	0.829	<.001	18	view →
ESCA	OS	Median	All	0.207	0.911	.001	12	view →
MESO	DFS	Median	All	0.099	0.392	.030	9	view →
LGG	DFS	Median	All	0.172	0.845	<.001	8	view →
READ	DFS	Median	II,III,IV	0.182	0.792	.016	6	view →
SCLC	OS	Median	IV	0.164	0.599	.001	6	view →
PRAD	DFS	Median	All	0.086	0.776	<.001	6	view →
LIHC	DFS	Median	II,III,IV	0.077	0.463	.002	6	view →
LUAD	DFS	Median	IV	0.671	0.893	.019	4	view →
SARC	DFS	Median	All	0.185	0.597	.010	3	view →
BLCA	OS	Median	III,IV	0.151	0.420	.026	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

LRRC7–UCEC (DFS)

Open the UCEC breakdown →