Across TCGA patient cohorts, LRRC69 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRC69-associated genes across cancer lineages are ASNS, ERK2, and MEK1. Each is linked with LRRC69 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC69-to-partner and partner-to-LRRC69 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC69→partner) and Y-score (partner→LRRC69) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.523	+2.115	<.001	.019	3	2
UCEC	ERK2 →	+0.205	+2.807	.015	.003	3	1
UCEC	MEK1 →	+0.350	+2.115	.028	.019	3	1
UCEC	Akt_pT308 →	+0.576	+2.999	.036	.035	3	1
UCEC	Annexin-1 →	+0.523	+3.019	.023	.019	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Exploration

LRRC69 survival (RNA) · tumor vs normal (RNA) · all LRRC69 data types