Across TCGA patient cohorts, LRRC66 mutation is significantly associated with the RNA expression of many other genes, with 4,213 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRC66-associated genes across cancer lineages are GTSE1, LINC01337, and SNRPD3. Each is linked with LRRC66 in more than 3 cancer types. Because this analysis shows association rather than direction, both LRRC66-to-partner and partner-to-LRRC66 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC66→partner) and Y-score (partner→LRRC66) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GTSE1 →	+0.606	+2.064	<.001	<.001	3	4
UCEC	LINC01337 →	+0.233	+2.180	.008	.001	3	4
UCEC	SNRPD3 →	+0.328	+2.523	<.001	<.001	3	4
UCEC	KIF2C →	+0.622	+2.928	<.001	<.001	3	4
UCEC	SHCBP1 →	+0.560	+2.673	<.001	<.001	3	4
UCEC	ORC1 →	+0.714	+2.758	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,213 associations by consensus.

Exploration

LRRC66 survival (RNA) · tumor vs normal (RNA) · all LRRC66 data types