Across TCGA patient cohorts, LRRC66 mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRC66-associated genes across cancer lineages are NF2, Caspase-7-cleavedD198, and GAPDH. Each is linked with LRRC66 in more than 2 cancer types. Because this analysis shows association rather than direction, both LRRC66-to-partner and partner-to-LRRC66 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC66→partner) and Y-score (partner→LRRC66) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	NF2 →	+0.211	+2.584	.005	.009	3	3
UCEC	Caspase-7-cleavedD198 →	+0.935	+2.341	<.001	<.001	3	3
UCEC	GAPDH →	+0.343	+2.584	.039	.010	3	3
UCEC	eIF4E →	+0.174	+2.713	.007	.003	3	2
LUSC	FASN →	+0.372	+1.331	.014	.044	3	2
LUSC	PDCD4 →	-0.371	-2.321	.011	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

Exploration

LRRC66 survival (RNA) · tumor vs normal (RNA) · all LRRC66 data types