Across TCGA cell cohorts, LRRC66 mutation is significantly associated with the RNA expression of many other genes, with 413 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LRRC66-associated genes across cancer lineages are HSFY2, HSFY1, and GALNTL5. Each is linked with LRRC66 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC66-to-partner and partner-to-LRRC66 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC66→partner) and Y-score (partner→LRRC66) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	HSFY2 →	+0.024	+4.930	<.001	.001	3	2
SKIN	HSFY1 →	+0.010	+5.022	<.001	.002	3	2
LUNG_NSCLC_LUAD	GALNTL5 →	+0.037	+3.374	<.001	.002	3	1
LUNG_NSCLC_LUAD	TRIM43B →	+0.026	+3.179	<.001	.004	3	1
LUNG_NSCLC_LUAD	OCSTAMP →	+0.014	+4.928	<.001	<.001	3	1
LUNG_NSCLC_LUAD	ASZ1 →	+0.294	+4.050	.004	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 413 associations by consensus.

Exploration

LRRC66 survival (RNA) · tumor vs normal (RNA) · all LRRC66 data types