LRRC6

Across TCGA patient cohorts, LRRC6 mutation is significantly associated with the RNA expression of many other genes, with 2,844 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRC6-associated genes across cancer lineages are RN7SL681P, KCNK18, and TRAJ5. Each is linked with LRRC6 in more than 2 cancer types. Because this analysis shows association rather than direction, both LRRC6-to-partner and partner-to-LRRC6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL681P grouped by LRRC6-low versus LRRC6-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC6→partner) and Y-score (partner→LRRC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RN7SL681P →	+0.107	+2.292	<.001	.003	3	3
SCLC	KCNK18 →	+0.056	+5.189	.003	.006	3	2
BLCA	TRAJ5 →	+0.617	+3.291	.006	.008	3	2
UCEC	RPP25 →	+0.601	+3.617	.003	.001	3	2
UCEC	LRRC57 →	+0.407	+3.354	.001	.005	3	2
SKCM	PSMG1 →	+0.486	+2.613	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,844 associations by consensus.

RN7SL681P by LRRC6 expression — SKCM

Explore this box plot interactively →