LRRC6

Across TCGA cell cohorts, LRRC6 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LRRC6-associated genes across cancer lineages are PRORY, DAZ3, and GJA8. Each is linked with LRRC6 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC6-to-partner and partner-to-LRRC6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRORY grouped by LRRC6-low versus LRRC6-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC6→partner) and Y-score (partner→LRRC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	PRORY →	+1.180	+4.807	<.001	.006	3	1
BLOOD_Myeloma	DAZ3 →	+1.563	+4.807	<.001	.006	3	1
BLOOD_Leukemia	GJA8 →	+0.019	+5.969	<.001	.001	3	1
BLOOD_Leukemia	DMRTC2 →	+0.025	+5.539	.002	.003	3	1
BLOOD_Leukemia	KCNA10 →	+0.006	+5.539	.001	.003	3	1
BLOOD_Leukemia	DCD →	+0.032	+5.969	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

PRORY by LRRC6 expression — BLOOD_Myeloma

Explore this box plot interactively →