LRRC59

Across TCGA pan-cancer cohorts, LRRC59 mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of LRRC59’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where LRRC59 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types LRRC59 is over-expressed in tumor, although a few such as PDAC show the opposite, repressed pattern.

HNSC, LUAD, and LSCC are the cancer types where LRRC59 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LRRC59 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+0.564	<.001	11	view →
LUAD	Female	III,IV	+1.022	<.001	9	view →
LSCC	Male	All	+0.948	<.001	9	view →
COAD	Male	All	+0.624	<.001	9	view →
CCRCC	All	III,IV	+0.298	<.001	9	view →
PDAC	Female	All	−1.287	<.001	6	view →
OV	All	All	+0.669	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

LRRC59–HNSC

Open the HNSC breakdown →