LRRC58

Across TCGA pan-cancer cohorts, LRRC58 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated LRRC58 data layer compared with 25 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher LRRC58 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated LRRC58 expression acts as an unfavorable survival marker, although some lineages such as LUAD and LSCC show a favorable association.

LUAD, CCRCC, and GBM are the cancer types where LRRC58 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.879	0.650	.007	22	view →
CCRCC	DFS	Tertile	II,III,IV	0.697	0.953	.008	13	view →
GBM	OS	Tertile	All	0.373	0.565	.023	10	view →
LSCC	DFS	Quartile	III,IV	1.000	0.419	.049	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

LRRC58–LUAD (OS)

Open the LUAD breakdown →