LRRC58

Across TCGA cell cohorts, LRRC58 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,951 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LRRC58-associated GO terms across cancer lineages are Double-strand break repair via nonhomologous end joining, Nuclear division, and Error-prone translesion synthesis. Each is linked with LRRC58 in more than 16 cancer types. Because this analysis shows association rather than direction, both LRRC58-to-partner and partner-to-LRRC58 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Double-strand break repair via nonhomologous end joining grouped by LRRC58-low versus LRRC58-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC58→partner) and Y-score (partner→LRRC58) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Double-strand break repair via nonhomologous end joining →	+0.060	+1.106	<.001	<.001	3	17
PANCREAS	Nuclear division →	+0.075	+0.842	.001	.003	3	16
LUNG_SCLC	Error-prone translesion synthesis →	+0.101	+0.650	.001	.003	3	16
LUNG_NSCLC_LUSC	DNA synthesis involved in DNA replication →	+0.090	+1.163	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Mitotic spindle assembly →	+0.088	+0.644	.001	.008	3	15
UPPER_AERODIGESTIVE_TRACT	Regulation of centrosome duplication →	+0.083	+0.828	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,951 associations by consensus.

Double-strand break repair via nonhomologous end joining by LRRC58 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →