LRRC58

Across TCGA cell cohorts, LRRC58 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LRRC58-associated genes across cancer lineages are C6orf118, DEFA4, and TMEM95. Each is linked with LRRC58 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC58-to-partner and partner-to-LRRC58 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C6orf118 grouped by LRRC58-low versus LRRC58-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC58→partner) and Y-score (partner→LRRC58) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C6orf118 →	+0.192	+3.793	<.001	.007	3	1
LARGE_INTESTINE	DEFA4 →	+0.032	+4.437	<.001	.004	3	1
LARGE_INTESTINE	TMEM95 →	+0.020	+4.437	<.001	.004	3	1
LARGE_INTESTINE	OR6Q1 →	+0.018	+4.437	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

C6orf118 by LRRC58 expression — LARGE_INTESTINE

Explore this box plot interactively →