LRRC56

Across TCGA pan-cancer cohorts, LRRC56 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated LRRC56 data layer compared with 28 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher LRRC56 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated LRRC56 expression acts as an unfavorable survival marker.

KIRC, HNSC, and OV are the cancer types where LRRC56 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.180	0.796	.001	24	view →
HNSC	DFS	Median	All	0.148	0.710	.005	21	view →
OV	OS	Median	All	0.244	0.690	.006	18	view →
BLCA	DFS	Median	IV	0.090	0.469	.009	12	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
LIHC	OS	Median	II,III,IV	0.239	0.715	.035	3	view →
SKCM	OS	Median	IV	0.133	0.621	.019	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

LRRC56–KIRC (DFS)

Open the KIRC breakdown →