LRRC56

Across TCGA patient cohorts, LRRC56 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRC56-associated genes across cancer lineages are 14-3-3_beta, TIGAR, and PCNA. Each is linked with LRRC56 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC56-to-partner and partner-to-LRRC56 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by LRRC56-low versus LRRC56-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC56→partner) and Y-score (partner→LRRC56) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.096	-2.446	.047	.020	3	1
UCEC	TIGAR →	+0.151	+2.486	.041	.011	3	1
UCEC	PCNA →	+0.206	+2.459	.049	.020	2	1
UCEC	p62 Lck ligand →	+0.416	+3.584	.008	.002	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

14-3-3_beta by LRRC56 expression — UCEC

Explore this box plot interactively →