LRRC56

Across TCGA cell cohorts, LRRC56 mutation is significantly associated with the RNA expression of many other genes, with 30 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LRRC56-associated genes across cancer lineages are FGF6, OR4D11, and KRTAP20-2. Each is linked with LRRC56 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC56-to-partner and partner-to-LRRC56 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FGF6 grouped by LRRC56-low versus LRRC56-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC56→partner) and Y-score (partner→LRRC56) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	FGF6 →	+0.225	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR4D11 →	+0.023	+6.266	<.001	<.001	3	1
LUNG_NSCLC_LUAD	KRTAP20-2 →	+0.245	+4.887	<.001	.009	3	1
BLOOD_Lymphoma	DMRTC2 →	+0.007	+4.058	<.001	.009	3	1
LARGE_INTESTINE	SEPTIN14 →	+0.009	+3.684	<.001	.006	3	1
LARGE_INTESTINE	C16orf96 →	+0.733	+4.237	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

FGF6 by LRRC56 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →