Across TCGA patient cohorts, LRRC55 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRC55-associated genes across cancer lineages are p38-MAPK_pT180_Y182, Annexin-1, and VHL. Each is linked with LRRC55 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC55-to-partner and partner-to-LRRC55 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC55→partner) and Y-score (partner→LRRC55) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK_pT180_Y182 →	-0.420	-2.000	.020	.030	3	2
UCEC	Annexin-1 →	+0.482	+2.341	.023	.019	3	2
UCEC	VHL →	-0.838	-2.000	.002	.030	3	2
SKCM	N-Ras →	+0.151	+1.584	.004	.035	3	2
UCEC	Ku80 →	+0.253	+2.331	.007	.019	3	1
UCEC	MAPK_pT202_Y204 →	-0.406	-2.000	.031	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Exploration

LRRC55 survival (RNA) · tumor vs normal (RNA) · all LRRC55 data types