LRRC53

Across TCGA pan-cancer cohorts, LRRC53 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated LRRC53 data layer compared with 1 for mutation status.

The strongest signal is observed in thyroid carcinoma (THCA), where higher LRRC53 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated LRRC53 expression acts as an unfavorable survival marker, although some lineages such as UCS and STAD show a favorable association.

THCA, DLBC, and ACC are the cancer types where LRRC53 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THCA	DFS	Tertile	IV	0.264	0.865	.001	93	view →
DLBC	OS	Tertile	II,III,IV	0.257	1.000	<.001	72	view →
ACC	DFS	Tertile	All	0.148	0.617	<.001	69	view →
LUSC	OS	Tertile	IV	0.001	0.673	.014	51	view →
KIRP	OS	Tertile	II,III,IV	0.111	0.769	<.001	36	view →
LIHC	OS	Tertile	III,IV	0.079	0.737	.004	27	view →
ESCA	OS	Tertile	II,III,IV	0.104	0.926	<.001	27	view →
UCEC	OS	Quartile	All	0.815	0.891	.009	20	view →
LUAD	DFS	Quartile	IV	0.290	0.755	.002	18	view →
UCS	DFS	Tertile	IV	0.975	0.514	.018	18	view →
STAD	OS	Tertile	IV	0.711	0.243	.012	18	view →
PAAD	DFS	Tertile	All	0.529	0.219	.008	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

LRRC53–THCA (DFS)

Open the THCA breakdown →