LRRC49

Across TCGA patient cohorts, LRRC49 mutation is significantly associated with the RNA expression of many other genes, with 2,938 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRC49-associated genes across cancer lineages are RNU6-709P, CXXC1, and SKA1. Each is linked with LRRC49 in more than 2 cancer types. Because this analysis shows association rather than direction, both LRRC49-to-partner and partner-to-LRRC49 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-709P grouped by LRRC49-low versus LRRC49-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC49→partner) and Y-score (partner→LRRC49) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNU6-709P →	+0.367	+4.233	<.001	.006	3	3
UCEC	CXXC1 →	+0.347	+1.700	.001	.002	3	3
COAD	SKA1 →	+0.837	+3.335	<.001	.005	3	3
UCEC	CHAF1B →	+0.578	+1.890	<.001	.001	3	3
UCEC	CPSF4 →	+0.310	+1.761	.004	.004	3	3
UCEC	ZFYVE19 →	+0.302	+2.272	.004	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,938 associations by consensus.

RNU6-709P by LRRC49 expression — BLCA

Explore this box plot interactively →