LRRC49

Across TCGA patient cohorts, LRRC49 mutation is significantly associated with the total protein of many other genes, with 61 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRC49-associated genes across cancer lineages are eIF4E, PCNA, and ASNS. Each is linked with LRRC49 in more than 2 cancer types. Because this analysis shows association rather than direction, both LRRC49-to-partner and partner-to-LRRC49 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by LRRC49-low versus LRRC49-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC49→partner) and Y-score (partner→LRRC49) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	eIF4E →	+0.288	+2.820	.001	.035	3	3
UCEC	PCNA →	+0.291	+3.807	<.001	<.001	3	3
COAD	ASNS →	+0.925	+3.178	<.001	.010	2	3
UCEC	mTOR_pS2448 →	-0.157	-2.482	.001	.001	3	2
UCEC	Notch1 →	+0.153	+1.807	.001	.004	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.451	-1.501	.003	.015	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 61 associations by consensus.

eIF4E by LRRC49 expression — COAD

Explore this box plot interactively →